N#-Hydroxy-nor-L-arginine, D 1PC X 5MG

Biochem/physiol Actions

Secondary Targetmouse macrophages (IC₅₀ = 50 µM)

Primary Targetarginase from rat liver

General description

A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC₅₀ = 2 µM) and mouse macrophages (IC₅₀ = 50 µM). Specifically interacts with the manganese-cluster of the enzyme active site. Does not act as a substrate or as an inhibitor of NOS. Hence, it may serve as a useful tool to study the interplays between arginase and NOS.

A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC₅₀ = 2 µM) and mouse macrophages (IC₅₀ = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Gobert, A.P., et al. 2000. Infect. Immun. 68, 4653.Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.Moali, C., et al. 2000. Biochemistry 39, 8208.Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.Moali, C., et al. 1998. Biochemistry 37, 10453.Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.

Packaging

1, 5 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)